Pier Luigi Carafa (1581-1655) was an Italian bishop and ecclesiastical diplomat.
- 1581: born in Naples
- 1624: appointed bishop of Tricarico, Italy. Ordained priest and bishop. Appointed Apostolic Nuncio to Germany.
- 1634: resigned as nuncio
- 1645: created cardinal; installed as Cardinal-Priest of SS. Silvestro e Martino ai Monti
- 1646: resigned as bishop of Tricarico, Italy
- 1655: died.